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papers

Roose lab publications are listed in chronological order.
We thank all our collaborators for the exciting team-based research.

2020

Cell Stem Cell
In press

Next generation surrogate Wnts support organoid growth and deconvolute Frizzled pleiotropy in vivo.

Yi Miao; Andrew Ha; Wim de Lau; Kanako Yuki; António J. M. Santos; Changjiang You; Maarten Geurts; Jens Puschhof; Cayetano Pleguezuelos-Manzano; Weng Chuan Peng; Ramazan Senlice; Carol Piani; Jan W. Buikema; Oghenekevwe M. Gbenedio; Mario Vallon; Jenny Yuan; Sanne de Haan; Wieger Hemrika; Kathrin Rösch; Luke T. Dang; David Baker; Melanie Ott; Philippe Depeille; Sean M. Wu; Jarno Drost; Roeland Nusse; Jeroen P. Roose; Jacob Piehler; Sylvia F. Boj; Claudia Y. Janda; Hans Clevers; Calvin J. Kuo; K. Christopher Garcia.

STAR Protocols
July 2020

Protocol for barcoding T cells combined with timed stimulations.

Kayla R. Kulhanek, Darienne R. Myers, Olga Ksionda, Yvonne Vercoulen, Damia Romero-Moya, and Jeroen P Roose.

Methods in Molecular Biology
Edition “Ras activity & Signalling”
In Press

Regulation of the small GTPase Ras and its relevance to human disease.

Kayla R. Kulhanek, Jeroen P. Roose, and Ignacio Rubio

STAR Protocols
March 2020

Protocol for comprehensive synthetic lethality screens.

Damia Romero-Moya & Jeroen P Roose

2019

Science
October

Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases.

Kondo Y, Ognjenović J, Banerjee S, Karandur D, Merk A, Kulhanek K, Wong K, Roose JP, Subramaniam S, Kuriyan J.

Cancers
September

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer.

Samocha A, Doh H, Kessenbrock K, Roose JP.

Immunological Reviews
September

mTOR and other effector kinase signals that impact T cell function and activity

Darienne R. Myers, Ben Wheeler, Jeroen P. Roose

JCI Insight
August

RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer

Oghenekevwe M. Gbenedio, Caroline Bonnans, Delphine Grun, Chih-Yang Wang, Ace J. Hatch, Michelle R. Mahoney, David Barras, Mary Matli, Yi Miao, K Christopher Garcia, Sabine Tejpar, Mauro Delorenzi, Alan P. Venook, Andrew B. Nixon, Robert S. Warren, Jeroen P. Roose and Philippe Depeille

Science Signaling
July

Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation

Jesse E. Jun*, Kayla R. Kulhanek*, Hang Chen, Arup Chakraborty, Jeroen P Roose

Cell Reports
May

Active Tonic mTORC1 Signals Shape Baseline Translation in Naïve T cells

Darienne R. Myers, Emilia Norlin, Yvonne Vercoulen and Jeroen P. Roose

Cell Reports
April

Resource: High-Complexity shRNA Libraries Predict Synthetic Lethality in the Context of PI3Kinase Inhibition with High Fidelity

Marsilius Mues, Laila Karra, Damia Romero Moya, Anica Wandler, Olga Ksionda, Yvonne Thus, Marthe Lindenbergh, Kevin Shannon, Michael McManus and Jeroen P. Roose

2018

PLoS ONE
May

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy

Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP.

2017

eLIFE
September

A Histidine pH Sensor Regulates Activation of the Ras-specific Guanine Nucleotide Exchange Factor RasGRP1

Yvonne Vercoulen*, Yasushi Kondo*, Jeffrey S. Iwig*, Axel B. Janssen, Katharine A. White, Mojtaba Amini, Diane L. Barber, John Kuriyan, and Jeroen P. Roose

Trends in Immunology
August

Tonic Signals: Why Do Lymphocytes Bother?

Darienne R. Myers, Julie Zikherman, and Jeroen P. Roose

Cell Reports
May

Tonic LAT-HDAC7 signals sustain Nur77 and Irf4 expression to tune naïve CD4 T cells

Darienne R. Myers*, Tannia Lau*, Evan Markegard, Hyung W. Lim, Herbert Kasler, Minghua Zhu, Andrea Barczak, John P. Huizar, Julie Zikherman, David J. Erle, Weiguo Zhang, Eric Verdin, and Jeroen P. Roose

Cancer Cell
May

RasGRP3 mediates MAPK pathway activation in GNAQ mutant uveal melanoma

Xu Chen, Qiuxia Wu, Philippe Depeille, Peirong Chen, Sophie Thornton, Helen Kalirai, Sarah E. Coupland, Jeroen P Roose, Boris C Bastian

2016

Nature Immunology
November

Lost GRP on Cytotoxicity?

Jeroen P. Roose

Nature Structural and Molecular Biology
August

One-way membrane trafficking of SOS in receptor-triggered Ras activation

Sune M. Christensen*, Hsiung-Lin Tu*, Jesse Jun*, Steven Alvarez, Meredith Triplet, Jeffrey S. Iwig, Kamlesh Yadav, Dafna Bar-Sagi, Jeroen P. Roose#, Jay T. Groves#

Encyclopedia of Immunobiology. 11006.
May

Kinase and Phosphatase Effector Pathways in T cells

Darienne R. Myers and Jeroen P. Roose

Small GTPases
May

Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle

Marsilius Mues and Jeroen P. Roose

Journal of Neuroscience
January

Human iPS cell-derived neurons uncover the impact of increased Ras Signaling in Costello Syndrome

Gemma Rooney, Alice Goodwin, Philippe Depeille, Amnon Sharir, Claude Schofield, Erika Yeh, Jeroen Roose, Ophir Klein, Katherine Rauen, Lauren Weiss, and Erik Ullian

2015

Oncogene
November

RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to pro-tumorigenic cytokines

Olga Ksionda, Alexis A. Melton, Juliane Bache, Milou Tenhagen, Jeroen Bakker, Richard Harvey, Stuart S. Winter, Ignacio Rubio and Jeroen P. Roose

Oncotarget

Unexpected insights for anti-EGFR cancer therapy

Philippe Depeille, Robert S. Warren, and Jeroen P. Roose

Cell Cycle
August

Flavors of EGFR-Ras signals impacting intestinal homeostasis

Philippe Depeille and Jeroen P. Roose

Nature Cell Biology
May

RasGRP1 Opposes Proliferative EGFR-SOS1 Ras Signals and Restricts Intestinal Epithelial Cell Growth

Philippe Depeille, Linda M. Henricks, Robert A. H. van de Ven, Ed Lemmens, Chih-Yang Wang, Mary Matli, Zena Werb, Kevin M. Haigis, David Donner, Robert Warren, and Jeroen Roose

Journal of Immunology
May

Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia

Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia

Beth A. Lubeck, Philip E. Lapinski, Jennifer A. Oliver, Olga Ksionda, Luis F. Parada, Yuan Zhu, Ivan Maillard, Mark Chiang, Jeroen Roose, and Philip D. King

Current Opinion in Immunology
April

Editorial overview: Lymphocyte development and activation: Lymphocytes, integrators of information

Jeroen Roose and Sidonia Fagarasan

2014

Global Medical Discovery
April

Global Medical Discovery

Andre Limnander and Jeroen P. Roose

Mol. Cell. Biology
April

PKCd promotes transitional B cell negative selection and limits proximal BCR signaling to enforce tolerance

Andre Limnander, Julie Zikherman, Tannia Lau, Michael Leitges, Arthur Weiss and Jeroen P. Roose

2013

eLIFE
December

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ CD44hi CD4+ T cells and autoantibodies

Stephen R. Daley*, Kristen M. Coakley*, Daniel Hu*, Katrina L. Randall*, Craig N. Jenne*, Andre Limnander*, Darienne R. Myers, Noelle K. Polakos, Anselm Enders, Carla Roots, Bhavani Balakishnan, Lisa A. Miosge, Geoff Sjollema, Edward M Bertram, Matthew A Field, Yunli Shao, T. Daniel Andrews, Belinda Whittle, S. Whitney Barnes, John R. Walker, Jason G. Cyster, Christopher C. Goodnow #, and Jeroen P. Roose #

Science Signaling
December

PLCgamma and PI3 Kinase Link Cytokine Stimulation to ERK Activation in Primary Hematopoietic Cells Expressing Normal and Oncogenic Kras

Ernesto Diaz-Flores, Hana Goldschmidt, Philippe Depeille, Victor Ng, Kimberly Krisman, Michael Crone, Olusegun Williams, Benjamin Houseman, Kevan Shokat, Deepak Sampath, Gideon Bollag, Jeroen P. Roose, Benjamin S. Braun, and Kevin Shannon

eLIFE
July

The Structural Basis for Autoinhibition of the Ras-specific exchange factor RasGRP1

Jeffrey S. Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G. Pelton, David E. Wemmer, Jeroen P. Roose# and John Kuriyan#

Frontiers in Biology
October

RasGRP Ras Guanine Nucleotide Exchange Factors in Cancer

Olga Kisionda, Andre Limnander, and Jeroen P. Roose

Frontiers in Immunology
September

Regulation of RasGRP and SOS Ras Exchange Factors by Lipid Messengers and Cellular Localization of Ras activation in T cells

Jesse Jun, Ignacio Rubio, and Jeroen P. Roose

Cell Cycle
May

Biochemical heterogeneity and developmental varieties in T-cell leukemia

Arup K. Chakraborty and Jeroen P. Roose

Mol. Cell. Biology
April

Activation of ERK but not of P38 MAP kinase Pathways in Lymphocytes Requires Allosteric Activation of SOS

Jesse Jun, Ming Yang, Hang Chen, Arup Chakraborty, and Jeroen Roose

Science Signaling
March

Dysregulated RasGRP1 Responds to Cytokine Receptor-input in T cell leukemogenesis

Catherine Hartzell*, Olga Ksionda*, Ed Lemmens*, Kristen Coakley, Ming Yang, Richard Harvey, Chris Govern, Jeroen Bakker, Tineke Lenstra, Monique Dail, Kristin Ammon, Anne Boeter, Mignon Loh, Stuart Winter, Arup Chakraborty, Kevin Shannon, Matthias Wabl, and Jeroen Roose

2012

Journal of Immunology
December

A PLC-gamma1-independent, RasGRP1-ERK dependent pathway drives lymphoproliferative disease in LAT-Y136F mutant mice

Robert L. Kortum, Alexander Rouquette-Jazdanian, Michihiko Miyaji, Robert K. Merrill, Evan Markegard, John M. Pinski, Amelia Wesselink, Nandan N. Nath, Clayton P. Alexander, Wenmei Li, Noemi Kedei, Jeroen P. Roose, Peter M. Blumberg, Lawrence E. Samelson, and Connie L. Sommers

J Phys Chem B
March

The Membrane Environment Can Promote or Suppress Bistability in Cell Signaling Networks

Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK

2011

PLoS ONE
September

Basal LAT-diacylglycerol-RasGRP1 Signals in T cells Maintain TCR-alpha Gene Expression

Evan Markegard, Evan Trager, Chih-wen Ou Yang, Weiguo Zhang, Arthur Weiss, and Jeroen P. Roose

Nature Immunology
May

Stim1, PKCdelta and RasGRP Proteins Set a Threshold for Pro-Apoptotic Erk Signaling During B cell Development

Andre Limnander, Philippe Depeille, Jen Liou, Michael Leitges, Tomohiro Kurosaki, Jeroen P. Roose and Arthur Weiss

2009

Nature
September

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

Jennifer O. Lauchle, Doris Ki, Doan T. Le, Keiko Akagi, Michael Crone, Kimberly Krisman, Kegan Warner, Jeannette M. Bonifas, Qing Li, Kristin M. Coakley, Ernesto Diaz-Flores, Matthew Gorman, Sally Przybranowski, Mary Tran, Scott C. Kogan, Jeroen P. Roose, Neal Copeland, Nancy Jenkins, Luis Parada, Linda Wolff, Judith Sebolt-Leopold, and Kevin Shannon

Science Signaling
April

Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes

Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, and Roose J.

Cell
January

Digital signaling and hysteresis characterize Ras activation in lymphoid cells

Jayajit Das, Mary Ho, Julie Zikherman, Christopher Gover, Ming Yang, Arthur Weiss, Arup K. Chakraborty, and Jeroen P. Roose

PNAS
January

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes

Ashok Prasad, Julie Zikherman, Jayajit Das, Jeroen Roose, Arthur Weiss, Arup K. Chakraborty