Roose Laboratory | University of California, San Francisco | Department of Anatomy | 513 Parnassus Avenue HSW 1330 | San Francisco CA 94143-0452
Roose Laboratory | University of California, San Francisco | Department of Anatomy | 513 Parnassus Avenue HSW 1330 | San Francisco CA 94143-0452
Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK.
The Membrane Environment Can Promote or Suppress Bistability in Cell Signaling Networks.
J Phys Chem B. 2012 Mar 13.
2011
Evan Markegard, Evan Trager, Chih-wen Ou Yang, Weiguo Zhang, Arthur Weiss, and Jeroen P. Roose.
Basal LAT-diacylglycerol-RasGRP1 Signals in T cells Maintain TCR-alpha Gene Expression.
PLoS ONE, 2011;6(9):e25540. Epub 2011 Sep 26.
Andre Limnander, Philippe Depeille, Jen Liou, Michael Leitges, Tomohiro Kurosaki, Jeroen P. Roose and Arthur Weiss.
Nature Immunology, 2011 May;12(5):425-33.
2009
Jennifer O. Lauchle, Doris Ki, Doan T. Le, Keiko Akagi, Michael Crone, Kimberly Krisman, Kegan Warner, Jeannette M. Bonifas, Qing Li, Kristin M. Coakley, Ernesto Diaz-Flores, Matthew Gorman, Sally Przybranowski, Mary Tran, Scott C. Kogan, Jeroen P. Roose, Neal Copeland, Nancy Jenkins, Luis Parada, Linda Wolff, Judith Sebolt-Leopold, and Kevin Shannon.
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
Nature. 2009 Sep 17;461(7262):411-4.
Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, and Roose J.
Science Signaling. 2009 2, 66:pt2.
Jayajit Das, Mary Ho, Julie Zikherman, Christopher Gover, Ming Yang, Arthur Weiss, Arup K. Chakraborty, and Jeroen P. Roose.
Digital signaling and hysteresis characterize Ras activation in lymphoid cells.
Cell. 2009 136, 337-351.
Chakraborty et al. and Das et al. (2009) describe how lymphocytes can send either analog or digital Ras-ERK signals depending on the use of the Ras activators RasGRP and SOS.
Ashok Prasad, Julie Zikherman, Jayajit Das, Jeroen Roose, Arthur Weiss, Arup K. Chakraborty.
Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.
PNAS. 2009 Jan 13;106(2):528-33.
Prasad et al. (2009) developed computational models for lymphocyte Ras activation to formulate hypotheses on thymocytes development.
Relevant earlier papers
Roose J, Mollenauer M, Ho M, Kurosaki T, and Weiss A.
Mol Cell Biol. 2007 27(7):2732-45
Roose J, Mollenauer M, Gupta V, Stone J, and Weiss A.
Mol. Cell Biol. 2005 25(11);4426-41.
Roose J, Diehn M, Tomlinson M, Lin J, Alizadeh A, Botstein D, Brown P, Weiss A.
T cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG gene Expression.
PLOS Biology. 2003 1(2):271-287.
Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H.
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Science. 1999 Sep 17;285(5435):1923-6.
Robert L. Kortum, Alexander Rouquette-Jazdanian, Michihiko Miyaji, Robert K. Merrill, Evan Markegard, John M. Pinski, Amelia Wesselink, Nandan N. Nath, Clayton P. Alexander, Wenmei Li, Noemi Kedei, Jeroen P. Roose, Peter M. Blumberg, Lawrence E. Samelson, and Connie L. Sommers
Journal of Immunology. 2012, Dec. 3
Catherine Hartzell*, Olga Ksionda*, Ed Lemmens*, Kristen Coakley, Ming Yang, Richard Harvey, Chris Govern, Jeroen Bakker, Tineke Lenstra, Monique Dail, Kristin Ammon, Anne Boeter, Mignon Loh, Stuart Winter, Arup Chakraborty, Kevin Shannon, Matthias Wabl, and Jeroen Roose.
Dysregulated RasGRP1 Responds to Cytokine Receptor-input in T cell leukemogenesis
Science Signaling. March 26, 2013.
2012
Hartzell et al. (2013). Growth of T cell leukemia cells.
Jesse Jun, Ming Yang, Hang Chen, Arup Chakraborty, and Jeroen Roose.
Mol. Cell. Biology, April, 2013
Jun et al. (2013).
A SOS1-P38 pathway.
Arup K. Chakraborty and Jeroen P. Roose.
Biochemical heterogeneity and developmental varieties in T-cell leukemia
Cell Cycle. May 15, 2013.
Jesse Jun, Ignacio Rubio, and Jeroen P. Roose.
Frontiers in Immunology, September 4, 2013.
Olga Ksionda, Andre Limnander, and Jeroen P. Roose.
RasGRP Ras Guanine Nucleotide Exchange Factors in Cancer.
Frontiers in Biology. October, 2013.
Jeffrey S. Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G. Pelton, David E. Wemmer, Jeroen P. Roose# and John Kuriyan#
The Structural Basis for Autoinhibition of the Ras-specific exchange factor RasGRP1.
eLIFE. July 30, 2013.
Stephen R. Daley*, Kristen M. Coakley*, Daniel Hu*, Katrina L. Randall*, Craig N. Jenne*, Andre Limnander*, Darienne R. Myers, Noelle K. Polakos, Anselm Enders, Carla Roots, Bhavani Balakishnan, Lisa A. Miosge, Geoff Sjollema, Edward M Bertram, Matthew A Field, Yunli Shao, T. Daniel Andrews, Belinda Whittle, S. Whitney Barnes, John R. Walker, Jason G. Cyster, Christopher C. Goodnow #, and Jeroen P. Roose #.
eLIFE. December 12, 2013.
Iwig et al. (2013).
Autoinhibited RasGRP1 structure
2014
2013
Andre Limnander, Julie Zikherman, Tannia Lau, Michael Leitges, Arthur Weiss and Jeroen P. Roose.
Mol. Cell. Biology. April, 2014.
Daley et al. (2013). Autoimmune pathology in Rasgrp1-Anaef mice.
Limnander et al. (2014). PKCd in negative selection of B cells and autoimmunity.
2016
Jeroen Roose and Sidonia Fagarasan
Editorial overview: Lymphocyte development and activation: Lymphocytes, integrators of information
Current Opinion in Immunology. April, 2015.
Philippe Depeille, Linda M. Henricks, Robert A. H. van de Ven, Ed Lemmens, Chih-Yang Wang, Mary Matli, Zena Werb, Kevin M. Haigis, David Donner, Robert Warren, and Jeroen Roose.
RasGRP1 Opposes Proliferative EGFR-SOS1 Ras Signals and Restricts Intestinal Epithelial Cell Growth
Nature Cell Biology. May 2015
Beth A. Lubeck, Philip E. Lapinski, Jennifer A. Oliver, Olga Ksionda, Luis F. Parada, Yuan Zhu, Ivan Maillard, Mark Chiang, Jeroen Roose, and Philip D. King.
Journal of Immunology. May 2015
Roose et al. (2007) describe how lymphocytes can use two different types of Ras activators; RasGRP or SOS.
Depeille et al. (2015). Suppressive RasGRP1 signals in colorectal cancer.
Philippe Depeille, Robert S. Warren, and Jeroen P. Roose
Unexpected insights for anti-EGFR cancer therapy
Oncotarget. August, 2015.
Olga Ksionda, Alexis A. Melton, Juliane Bache, Milou Tenhagen, Jeroen Bakker, Richard Harvey, Stuart S. Winter, Ignacio Rubio and Jeroen P. Roose
Oncogene. November 2015.
Philippe Depeille and Jeroen P. Roose
Flavors of EGFR-Ras signals impacting intestinal homeostasis
Cell Cycle. August, 2015.
Ksionda et al. (2015). Constitutive GTP-loading of Ras in RasGRP1 leukemia.
Darienne R. Myers and Jeroen P. Roose
Kinase and Phosphatase Effector Pathways in T cells
Encyclopedia of Immunobiology. 11006. May 2016.
Myers & Roose (2016).
Cartoon of Ras activation by the RasGEFs RasGRP and SOS.
Gemma Rooney, Alice Goodwin, Philippe Depeille, Amnon Sharir, Claude Schofield, Erika Yeh, Jeroen Roose, Ophir Klein, Katherine Rauen, Lauren Weiss, and Erik Ullian
Human iPS cell-derived neurons uncover the impact of increased Ras Signaling in Costello Syndrome
Journal of Neuroscience. January 2016
2015
Marsilius Mues and Jeroen P. Roose
Small GTPases. May 2016.
Ernesto Diaz-Flores, Hana Goldschmidt, Philippe Depeille, Victor Ng, Kimberly Krisman, Michael Crone, Olusegun Williams, Benjamin Houseman, Kevan Shokat, Deepak Sampath, Gideon Bollag, Jeroen P. Roose, Benjamin S. Braun, and Kevin Shannon.
Science Signaling. December 3, 2013.
Sune M. Christensen*, Hsiung-Lin Tu*, Jesse Jun*, Steven Alvarez, Meredith Triplet, Jeffrey S. Iwig, Kamlesh Yadav, Dafna Bar-Sagi, Jeroen P. Roose#, Jay T. Groves#
One-way membrane trafficking of SOS in receptor-triggered Ras activation
Nature Structural and Molecular Biology. August 2016
Christensen, Tu, and Jun. (2016). SOS regulation during receptor-Ras signals.
2017
Xu Chen, Qiuxia Wu, Philippe Depeille, Peirong Chen, Sophie Thornton, Helen Kalirai, Sarah E. Coupland, Jeroen P Roose, Boris C Bastian.
RasGRP3 mediates MAPK pathway activation in GNAQ mutant uveal melanoma
Cancer Cell. May 2017
Darienne R. Myers*, Tannia Lau*, Evan Markegard, Hyung W. Lim, Herbert Kasler, Minghua Zhu, Andrea Barczak, John P. Huizar, Julie Zikherman, David J. Erle, Weiguo Zhang, Eric Verdin, and Jeroen P. Roose.
Tonic LAT-HDAC7 signals sustain Nur77 and Irf4 expression to tune naïve CD4 T cells
Cell Reports. May 2017
Myers & Lau. (2017). A tonic LAT-HDAC7 signal to curb naive T cells
Darienne R. Myers, Julie Zikherman, and Jeroen P. Roose.
Tonic Signals: Why Do Lymphocytes Bother?
Trends in Immunology. August 2017
Yvonne Vercoulen*, Yasushi Kondo*, Jeffrey S. Iwig*, Axel B. Janssen, Katharine A. White, Mojtaba Amini, Diane L. Barber, John Kuriyan, and Jeroen P. Roose.
eLIFE. September 2017
Vercoulen & Kondo & Iwig (2017). A Histidine pH sensor in RasGRP1..