Roose Lab

Department of Anatomy
LAB PAPERSLab_Papers.html

Our goal is to understand how different flavors of receptor triggered Ras signals drive normal developmental processes of various cell types and organ systems and how (and why) perturbations of Ras-kinase signals cause human disease.

A large body of our work focuses on the role of the Ras exchange factors in the Ras signaling pathway. This pathway is critical for many normal physiological processes such as lymphocyte development and deregulated with very high frequency in many types of cancer.

Through multiple collaborations, we integrate different research disciplines into our research program. By bridging biophysical-, computational-, and novel technological- approaches with our biochemical investigations of cell lines, mouse models, and patient samples, we strive to obtain entirely new insights into the mechanisms that underly  autoimmune diseases, leukemia, and carcinomas.

We are grateful for the financial support from the following agencies:

NIH/NIAID (P01 Program Project - AI091580)                            NIH/NIAID (R01 - AI104789)                NIH/NCI (R01 - CA187318)                        NIH/NHLBI (R01 - HL120724)

Alex’ Lemonade Stand Foundation Innovator Award              Leukemia & Lymphoma Society

Roose Laboratory | University of California, San Francisco | Department of Anatomy | 513 Parnassus Avenue HSW 1330 | San Francisco CA 94143-0452

Website figures by Anna Hupalowska