Roose Lab

Department of Anatomyhttp://anatomy.ucsf.edu/
 
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Our goal is to understand how different flavors of receptor triggered Ras signals drive normal developmental processes of various cell types and organ systems and how (and why) perturbations of Ras-kinase signals cause human disease.


We take a very collaborate approach and integrate different research disciplines into our research program. By bridging biophysical-, computational-, and novel technological- approaches with our biochemical investigations of cell lines, mouse models, and patient samples, we strive to obtain entirely new insights into the mechanisms that underly  autoimmune diseases, leukemia, and carcinomas.

We are grateful for the financial support from the following agencies:


NIH/NIAID         (P01 Program Project - AI091580)

NIH/NIAID         (R01 - AI104789)

NIH/NCI             (R01 - CA187318)

NIH/NHLBI        (R01 - HL120724)

NIH                    (F31 - CA200342)

Alex’ Lemonade Stand Foundation Innovator Award

Leukemia & Lymphoma Society

Roose Laboratory | University of California, San Francisco | Department of Anatomy | 513 Parnassus Avenue HSW 1330 | San Francisco CA 94143-0452

Website figures by Anna Hupalowska

Latest news !


July 2016: Jesse’s paper accepted in Nature Structural and Molecular Biology


May 2016: Marsilius’ highlight in Small GTPases on Olga’s paper